关键词: 去乙酰基长春花碱酰胺硫酸盐, 大鼠, 生殖毒性, 胚胎毒性, 致畸作用, 生育能力

Abstract: The reproductive toxicity of vindesine sulfate (VDS) in Wistar rat s was carried out . Before mating trial , VDS was iv given once a week at 0. 05 , 0. 1 and 0. 2 mg/ kg to male rat s (9 doses) and to female rats (3doses) . The administ ration was same to both rat s during the mating t rial (1∶1 cohabitation , for up to 2 weeks)and to mated females on day 6 and 12 postcoitus (pc) . Mated females were killed on day 20 pc. As compared to the saline cont rol , the body weight gain of males f rom every dosage group is less. In high dosage of VDS ( 0. 2mg/ kg) , the percentage of dead fetus is higher and the tail length and body weight of survival fetuses is less.The percentage of delayed skeletogency of every dosage group is higher. No malformation of survival fetuses was observed in every group. The study indicated that VDS is embryotoxic but not teratogenic in Wistar rats and has no obvious effect on reproductive performance of both sexes.

Key words: vindesine sulfate (VDS), reproductive toxicity, embryotoxicity, teratogenicity, reproductive performance